Inderal reduces the energy used by the heart to pump blood around the body, and so reduces the heart's need for oxygen, which means it can also be used in the management of angina. If you have ischemic heart disease. Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and heart failure. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. Propranolol may reduce the oxygen requirement of the heart at any level of effort by blocking catecholamine induced increases in the heart rate, low blood pressure and heart failure. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and the velocity and extent of myocardial contraction. Care should be taken if adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals.
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