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What should my health care professional know before I take Esomeprazole? For while taking Esomeprazole? What should my health care professional know before I take Esomeprazole? Esomeprazole works best if taken on an empty stomach at least one hour before a meal. In patients with gastroesophageal reflux disease, Esomeprazole has demonstrated pharmacological and clinical benefits beyond those seen with the other proton pump inhibitors. For the majority of gastric ulcers.
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