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Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and slow heart rate. Several reports in the published literature describe cases in which Propranolol was used as a suicide agent. You should not stop taking this medicine suddenly, particularly if you have ischemic heart disease. Beta-blockers. The gastrointestinal tract. In combination with clonidine to lower blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. Treatment with Propranolol, laboratory determinations should be made at regular intervals. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised.
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